Physical and Chemical Properties | Biodegradable biological materials with chemical properties, good biocompatibility, and long-term degradation cycle (6 months). |
Use | Use diazepam-polyhydroxybutyrate microspheres for intramuscular injection control drugs, not only can reduce drug side effects, improve efficacy, prolong drug action time, and convenient for patients. |
preparation of diazepam-polyhydroxybutyrate (DZP-PHB) microspheres: prepared by solvent evaporation method, polyhydroxybutyrate and diazepam are proportionally weighed and dissolved in dichloromethane, and under stirring, the aqueous phase containing 1% polyvinyl alcohol emulsifier is added drop by drop, the rotation speed of the microspheres is 1000r /min after stirring for 8 hours, centrifugation for 5 hours, washing with distilled water for five times.
DZP-PHB microspheres were released at a constant temperature of 37 ℃ for 37d in 500ml (pH = 7.4 containing 0.04% sodium azide phosphate buffer).